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Public Library of Science, PLoS ONE, 10(8), p. e76453, 2013

DOI: 10.1371/journal.pone.0076453

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Long-Term Functional Outcomes and Correlation with Regional Brain Connectivity by MRI Diffusion Tractography Metrics in a Near-Term Rabbit Model of Intrauterine Growth Restriction

Journal article published in 2013 by Miriam Illa, Elisenda Eixarch, Dafnis Batalle ORCID, Ariadna Arbat-Plana, Emma Muñoz-Moreno, Francesc Figueras, Eduard Gratacos
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Intrauterine growth restriction (IUGR) affects 5–10% of all newborns and is associated with increased risk of memory, attention and anxiety problems in late childhood and adolescence. The neurostructural correlates of long-term abnormal neurodevelopment associated with IUGR are unknown. Thus, the aim of this study was to provide a comprehensive description of the long-term functional and neurostructural correlates of abnormal neurodevelopment associated with IUGR in a near-term rabbit model (delivered at 30 days of gestation) and evaluate the development of quantitative imaging biomarkers of abnormal neurodevelopment based on diffusion magnetic resonance imaging (MRI) parameters and connectivity.