Wiley, Journal of Cutaneous Pathology, 1(41), p. 58-62
DOI: 10.1111/cup.12248
Full text: Unavailable
Mycosis fungoides (MF) represents the most common epidermotropic cutaneous T-cell lymphoma (CTCL), and tumor cells typically express a mature T-helper memory phenotype. A minority of MF patients display an unusual phenotype, which may be either CD4(-)/CD8(+) or double negative. Herein, we report a case of biopsy-proven MF in a 31 year-old woman who presented with infiltrated plaques involving photoprotected areas of the skin. Immunohistochemical study combined with confocal microscopy revealed co-expression of CD4 and CD8 in a subset of atypical T-lymphocytes. To our knowledge, this is the second report of a CD4/CD8 dual-positive MF.