Published in
Springer (part of Springer Nature), Annals of Surgical Oncology
DOI: 10.1245/s10434-015-5061-7
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Perioperative Treatment, Not Surgical Approach, Influences Overall Survival in Patients with Gastroesophageal Junction Tumors: A Nationwide, Population-Based Study in The Netherlands
,
Misha D. P. Luyer,
Luyer Md,
Ruurda Jp,
Jelle P. Ruurda,
Richard van Hillegersberg,
Valery E. P. P. Lemmens,
Lemmens Ve,
Nieuwenhuijzen Ga,
Grard A. P. Nieuwenhuijzen
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Abstract
BACKGROUND: Resectable gastroesophageal junction (GEJ) tumors are treated either with an esophageal-cardia resection or with gastrectomy. The difference in outcome between these two treatment modalities is unknown; Therefore, the aim of this study was to evaluate population-based treatment strategies for patients with resectable adenocarcinomas of the GEJ and to compare the oncological outcomes. METHODS: Patients with potentially resectable GEJ tumors diagnosed between 2005 and 2012 were selected from the nationwide, population-based Netherlands Cancer Registry. Differences between patients were compared using the χ (2) test, and survival curves were generated using the Kaplan-Meier method. Overall multivariate survival was assessed using Cox regression analyses. RESULTS: Patients treated with esophagectomy (n = 939) were significantly younger than patients treated with gastrectomy (n = 257; 64 vs. 66 years; p