Published in

BioMed Central, BMC Infectious Diseases, 1(14), 2014

DOI: 10.1186/s12879-014-0693-y

Links

Tools

Export citation

Search in Google Scholar

Ibuprofen versus mecillinam for uncomplicated cystitis - a randomized controlled trial study protocol

Journal article published in 2014 by Ingvild Vik ORCID, Marianne Bollestad, Nils Grude, Anders Bærheim, Sigvard Mölstad, Lars Bjerrum ORCID, Morten Lindbæk
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Abstract Background Although uncomplicated cystitis is often self-limiting, most such patients will be prescribed antibiotic treatment. We are investigating whether treatment of cystitis with an NSAID is as effective as an antibiotic in achieving symptomatic resolution. Methods/Design This is a randomized, controlled, double blind trial following the principles of Good Clinical Practice. Women between the ages of 18 to 60 presenting with symptoms of uncomplicated cystitis are screened for eligibility. 500 women from four sites in Norway, Sweden and Denmark are allocated to treatment with 600 mg ibuprofen three times a day or 200 mg mecillinam three times a day for three days. Allocation is conducted using block randomization. The primary outcome is the number of patients who feel cured by day four as recorded in a diary. Adverse events will be handled and reported in accordance with Good Clinical Practice. Discussion If treatment of uncomplicated cystitis with ibuprofen is as effective as mecillinam for symptom relief, we can potentially reduce the use of antibiotics on a global scale. Trial registration EudraCTnr: 2012-002776-14. ClinicalTrials.gov: NCT01849926 .