Published in
American Association for the Advancement of Science, Science, 6263(350), p. 985-990, 2015
Links
- ORCID
- ORCID
- American Association for the Advancement of Science
- [repository.bilkent.edu.tr] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [repository.bilkent.edu.tr] | PDF
Tools
Patrolling monocytes control tumor metastasis to the lung
,
Heba Nowyhed,
Erica Herrley,
Nicole Rasquinha,
Sara McArdle,
Runpei Wu,
Esther Peluso,
Daniel Metzger ,
Hiroshi Ichinose,
Iftach Shaked,
Grzegorz Chodaczek
and other authors.
Full text: Download
Abstract
Monocytes block tumor access to the lung Metastatic cancer is especially hard to treat. In order to find potential new therapeutic targets, scientists are trying to understand the cellular events that promote or prevent metastasis. Hanna et al. now report a role for patrolling monocytes in blocking tumor metastasis to the lungs in mice. Tumors in mice engineered to lack patrolling monocytes showed increased metastasis to the lung but not to other tissues. Patrolling monocytes resided in the microvasculature of the lung, where they engulfed tumor material, which may explain how these cells prevent tumors from colonizing the lung. Science , this issue p. 985