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American Physical Society, Physical Review Letters, 15(108), 2012

DOI: 10.1103/physrevlett.108.158103

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Critical Behavior and Axis Defining Symmetry Breaking inHydraEmbryonic Development

Journal article published in 2012 by Andrea Gamba, Mario Nicodemi ORCID, Jordi Soriano, Albrecht Ott
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.