The oxidative dehydrogenation (ODH) of propane have been studied on three different vanadium oxide catalysts, containing comparable amounts of vanadium. All the proven catalysts have been prepared by grafting but following different procedures. One has been prepared by grafting vanadyl tri-isopropoxide, dissolved in n-hexane on a support of silica coated with a multi-layer of TiO2. The support has been prepared by grafting in three different steps titanium alkoxide on silica. Another catalyst has been prepared by partially hydrolysing vanadyl tri-isopropoxide, dissolved in isopropanol, before grafting the obtained product on the same support. The third catalyst has been prepared by reacting partially hydrolysed vanadyl tri-isopropoxide with titanium alkoxide in isopropanol and anchoring then the reaction product, a vanadium–titanium bimetallic alkoxide, directly on silica. The first and second catalysts have similar activities and selectivities, while the third catalyst is less active but more selective than the other two ones. A kinetic approach has been made and a pseudo-first order kinetic law has been used to interpret the results. All the observed catalytic phenomena have been interpreted also with the aid of the several used characterisation techniques.