We present the mass and X-ray temperature functions derived from a sample of more than 15,000 galaxy clusters of the MareNostrum Universe cosmological SPH simulations. In these simulations, we follow structure formation in a cubic volume of 500/h Mpc on a side assuming cosmological parameters consistent with either the first or third year WMAP data and gaussian initial conditions. We compare our numerical predictions with the most recent observational estimates of the cluster X-ray temperature functions and find that the low normalization cosmological model inferred from the 3 year WMAP data results is barely compatible with the present epoch X-ray cluster abundances. We can only reconcile the simulations with the observational data if we assume a normalization of the Mass-Temperature relation which is a factor of 2.5--3 smaller than our non-radiative simulations predict. This deviation seems to be too large to be accounted by the effects of star formation or cooling in the ICM, not taken into account in these simulations. Comment: 4 pages, 3 figures. Accepted for publication in The Astrophysical Journal Letters