Elsevier, Alzheimer's && Dementia :: Diagnosis, Assessment && Disease Monitoring, 1(2), p. 19-26, 2015
DOI: 10.1016/j.dadm.2015.11.003
Full text: Download
Cognitive composite scores developed for preclinical Alzheimer's disease (AD) often consist of multiple cognitive domains as they may provide greater sensitivity to detect β-amyloid (Aβ)–related cognitive decline than episodic memory (EM) composite scores alone. However, this has never been empirically tested. We compared the rate of cognitive decline associated with high Aβ (Aβ+) and very high Aβ (Aβ++) in cognitively normal (CN) older adults on three multidomain cognitive composite scores and one single-domain (EM) composite score.