Elsevier, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1-2(736), p. 130-137, 2012
DOI: 10.1016/j.mrfmmm.2012.03.003
Full text: Download
Glutathione S-transferases (GSTs) are members of a multigene family of isoenzymes that are important in the control of oxidative stress and in phase II metabolism. Acting non-enzymically, GSTs can modulate signalling pathways of cell proliferation, cell differentiation and apoptosis. Using a molecular epidemiology approach, we have investigated a potential involvement of GSTs in DNA damage processing, specifically the modulation of DNA repair in a group of 388 healthy adult volunteers; 239 with at least 5 years of occupational exposure to asbestos, stone wool or glass fibre, and 149 reference subjects.