Table S1 Variants of unknown frequency and of frequency ≤1% in HAPMAP CEU or 1000G CEU when HAPMAP frequency was not available, identified in at least 1 of the 7 sequenced individuals in Families A, B and C. Table S2 Genes that contain rare functional variants shared among all the members of each family. Table S3 Genes that contain rare functional variants shared between two of the three families.