Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules
Journal article published in 2010 by
Yan Yan 
,
Christopher J. Ochs,
Georgina K. Such,
Joan K. Heath,
Edouard C. Nice,
Frank Caruso
,
Christopher J. Ochs,
Georgina K. Such,
Joan K. Heath,
Edouard C. Nice,
Frank Caruso
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Abstract
Biodegradable polymer capsules with drug-loaded multilayers were prepared through click chemistry via layer-by-layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro. Endocytosis of drug-loaded capsules leads to bypass of Pgp-mediated multidrug resistance in cancer cells.