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Wiley, European Journal of Immunology, 9(42), p. 2285-2289, 2012

DOI: 10.1002/eji.201242852

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T cell exhaustion due to persistent antigen: Quantity not quality?

Journal article published in 2012 by Elina I. Zuniga, James A. Harker ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

T-cell exhaustion is characterized by failure to respond to a persistent antigen and is a hallmark of chronic infections and cancer. Here, we discuss several recent reports on T-cell exhaustion, including one in this issue of the European Journal of Immunology where Richter et al. [Eur. J. Immunol. 42:2290-2304] examine the importance of the amount of persistent antigen versus the cell type presenting it to induce CD8(+) T-cell exhaustion, and the consequences for host survival during chronic viral infection.