Nkh477 Inhibits Proliferation and Induces Apoptosis in a Panel of Cancer Cell Lines
Journal article published in 2010 by
Faris Alenzi,
Saad Alghamdi 
Abstract
Background and Objectives: The anti-proliferative effects of cAMP in cancer cells may be regulated by the adenylyl-cyclase-V isoform. As Colforsin Daropate (NKH477) is more selective for this isoform, we hypothesized that this water soluble compound may promise utility as an oral anti-tumour agent.