The objective of this work was to analyze the effect of grain moisture and crop yield spatial distribution on grain losses and quality during bean uprooting, collecting, threshing and separating process on a retirement-threshing machine. The work was performed in a 35 ha area under a central pivot irrigation system. Grain moisture on the uprooting and collecting process, the crop yield, the machine work speed, the grain losses during uprooting, collecting, threshing and separating process and the material-other-than-grain were measured. Grain losses and product quality displayed high variation over the area, showing the need for a specific regulation of the retirement-threshing machine on each case during the harvest, in function of the grain moisture and crop yield.