The introductions of new technologies, especially the Internet, have opened up new possibilities for continuing medical education (CME) in the form of e-learning. This review article describes the opportunities for CME e-learning. CME regulations and e-learning options have been developed by the Croatian Medical Chamber and the Croatian Chamber of Pharmacists. In the past decade several e-learning courses for physicians and one for pharmacists have been posted online. However, only the PLIVAmed.net Internet portal has maintained the continuity of e-courses. These courses are run in collaboration with professional societies, professors from schools of medicine and pharmacy and experts from the relevant chambers. Further investigations are needed in Croatia to determine e-learning needs, attitudes and experiences and thus use the advantages of modern technologies in lifelong learning.