Published in
Elsevier, Nuclear Medicine and Biology, 3(43), p. 198-205, 2016
DOI: 10.1016/j.nucmedbio.2015.12.002
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Comparison of 18F-FET and 18F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma
Journal article published in 2015 by
Mette Kjoelhede Nedergaard,
Signe Regner Michaelsen,
Lara Perryman,
Janine Erler,
Hans Skovgaard Poulsen,
Marie-Thérése Stockhausen,
Ulrik Lassen 
,
Andreas Kjaer
,
Andreas Kjaer
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Abstract
The radiolabeled amino acid O-(2-18F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3’-deoxy-3’-18F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET PET for the assessment of anti-VEGF response in glioblastoma xenografts.