Fluconazole is used in treatment of the surface mycoses of the skin. Menthol, salicylic acid and benzocaine are the components of many preparations for topical use. When mixed they form the eutectic mixtures. The purpose of our research was to prepare the antifungal creams with fluconazole containing eutectic mixture: menthol-salicylic acid or menthol-benzocaine and to compare and estimate the influence of these mixtures on physical properties of these preparations. At the beginning, the creams were subjected to physical tests such as spreadability, slip and tenacity. Further, the rheological properties were evaluated. The fluconazole creams with eutectic mixtures had better physical properties. The rheological studies, based on Ostwald de Waele model, showed the pseudoplastic character of flowing at 32°C and the correlation between the rheological parameters and the composition of the creams. Moreover, all the preparations had thixotropic properties. 2013