The crustal structure of north-central Wyoming records a history of complex lithospheric evolution from Precambrian accretion to Cretaceous-Paleogene Laramide shortening. We present two active source P-wave velocity model profiles collected as part of the Bighorn Arch Seismic Experiment (BASE) in 2010. Analysis of these velocity models and single-fold reflection data, together with potential field modeling of regional gravity and magnetic signals, constrains crustal structure and thickness of the Bighorn region. We image a west-dipping reflection boundary and model a sharp magnetic contact east of the Bighorn Arch that together may delineate a previously undetected Precambrian suture zone. Localized patches of a high-velocity, high-density lower crustal layer (the '7.× layer') occur across the study area, but are largely absent beneath the Bighorn Arch culmination. Moho topography is relatively smooth with no large-scale offsets, with depths ranging from ~50-37 km, and is largely decoupled from Laramide basement topography. These observations suggest that: 1) the edge of the Archean Wyoming craton lies just east of the Bighorn Mountains, approximately 300 km west of previous interpretations; and 2) Laramide deformation localized in an area with thin or absent 7.× layer, due to its relatively weak lower crust, leading to detachment faulting. Our findings show that Precambrian tectonics in northern Wyoming may be more complicated than previously determined and subsequent Laramide deformation may have been critically dependent on laterally heterogeneous crustal structure that can be linked to Precambrian origins.