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Humana Press, Methods in Molecular Biology, p. 193-213, 2006

DOI: 10.1007/978-1-60761-058-8_12

Humana Press, Methods in Molecular Biology, p. 199-224

DOI: 10.1007/978-1-4939-3661-8_12

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Skin diseases in laboratory mice: approaches to drug target identification and efficacy screening.

Book chapter published in 2006 by John P. Sundberg, Kathleen A. Silva, Caroline McPhee, Lloyd E. King, C. Herbert Pratt ORCID
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Abstract

A large variety of mouse models for human skin and adnexa diseases are readily available from investigators and vendors worldwide. While the skin is an obvious organ to observe lesions and their response to therapy, actually treating and monitoring progress in mice can be challenging. This chapter provides an overview on how to use the laboratory mouse as a preclinical tool to evaluate efficacy of a new compound or test potential new uses for a compound approved for use for treating an unrelated disease. Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented.