Published in
Sociedade Brasileira de Química, Química Nova, 2(37)
DOI: 10.5935/0100-4042.20140049
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Chemical constituents of the stem bark ofVochysia thyrsoideaPohl. (Vochysiaceae) and evaluation of their cytotoxicity and inhibitory activity against cathepsins B and K.
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Paulo Cezar Vieira,
Maísa Borges Costa,
Mirley Luciene dos Santos,
Aline Borba Sbardelotto,
Cláudia do Ó. Pessoa,
Manoel Odorico de Moraes,
Antônio Carlos Severo Menezes
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Abstract
A new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-alpha-rhamnopyranoside, along with known compounds, catechin-3-O-alpha-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer cell lines. Catechin-3-O-(3"-O-trans-cinnamoyl)-alpha-rhamnopyranoside showed moderate inhibitory activity (IC50 = 62.02 mu M) against cathepsin B while 2-butyl-D-fructofuranoside was the most potent against a strain of CNS (SF-295) and human leukemia (HL-60) with IC50 = 36.80 mu M and IC50 = 25.37 mu M, respectively.