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Elsevier, Methods, 1(66), p. 3-21, 2014

DOI: 10.1016/j.ymeth.2013.07.024

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Structure of Allergens and Structure Based Epitope Predictions

Journal article published in 2014 by Fabio Dall’Antonia, Tea Pavkov-Keller, Klaus Zangger, Walter Keller ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The structure determination of major allergens is a prerequisite for analyzing surface exposed areas of the allergen and for mapping conformational epitopes. These may be determined by experimental methods including crystallographic and NMR-based approaches or predicted by computational methods. In this review we summarize the existing structural information on allergens and their classification in protein fold families. The currently available allergen-antibody complexes are described and the experimentally obtained epitopes compared. Furthermore we discuss established methods for linear and conformational epitope mapping, putting special emphasis on a recently developed approach, which uses the structural similarity of proteins in combination with the experimental cross-reactivity data for epitope prediction.