Street littering is considered an important environmental health issue in the Middle East. This problem is growing steadily and is attracting great concerns within the communities. The purpose of this paper, which focuses on Nablus district (Palestinian Territory), is to measure the perception and opinion of residents toward littering, in addition to studying prevailing attitudes and practices on littering. This was achieved using an interview survey approach. The influence of three socio-economic factors; level of education, age, and type of residence, on the littering behaviour of individuals was studied. As a result, possible remedial actions have been suggested. The data presented in this work can be considered as one piece of information, which can be compiled with other future data to design an effective litter control programme for Middle Eastern countries.