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Public Library of Science, PLoS ONE, 12(5), p. e15735, 2010

DOI: 10.1371/journal.pone.0015735

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Predictors of Multidrug- and Extensively Drug-Resistant Tuberculosis in a High HIV Prevalence Community

Journal article published in 2010 by Jason R. Andrews, N. Sarita Shah, Darren Weissman, Anthony P. Moll, Gerald Friedland, Neel R. Gandhi ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) have emerged in high-HIV-prevalence settings, which generally lack laboratory infrastructure for diagnosing TB drug resistance. Even where available, inherent delays with current drug-susceptibility testing (DST) methods result in clinical deterioration and ongoing transmission of MDR and XDR-TB. Identifying clinical predictors of drug resistance may aid in risk stratification for earlier treatment and infection control.