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MDPI, Molecules, 11(18), p. 14285-14292, 2013

DOI: 10.3390/molecules181114285

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Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Journal article published in 2013 by Tran Dinh Thang, Ping-Chung Kuo, Tsong-Long Hwang, Mei-Lin Yang, Nguyen Thi Bich Ngoc, Tran Thi Ngoc Han, Chi-Wen Lin, Tian-Shung Wu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.