Two syntopic species of Cnemidophorus are described from the Caatingas of the Parque Nacional da Serra das Confusões (PNSC), located in the Southwestern region of the state of Piauí in Brazil. Both species are assigned to the ocellifer group, differing from all other members of the group by their distinct color pattern and lepidosis. Besides these differences, both new species share a number of particular features with other members of the group. One of them, C. venetacaudus, shares with C. abaetensis and C. littoralis the presence of spurs in the heels of males, six supraciliar scales, a high number of femoral pores (from 21–45), a row of enlarged scales in the dorsal region of the arm, 8–10 rows of ventral scales, and a bright bluish-green tail, while the other species, C. confusionibus, shares with C. ocellifer, C. mumbuca, and C. jalapensis a low number of femoral pores, enlarged scales in the temporal region (posterior to third subocular), 5 supraciliar scales, and 6–8 rows of ventral scales. Based on these comparisons, we suggest that the ocellifer group is more complex than previously admitted, being composed by at least two morphologically recognizable species subgroups.