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American Chemical Society, Journal of Natural Products, 12(64), p. 1552-1555, 2001

DOI: 10.1021/np0102307

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New Sesquiterpene Derivatives from the Red AlgaLaurenciascoparia.Isolation, Structure Determination, and Anthelmintic Activity1

Journal article published in 2001 by Danilo Davyt ORCID, Rafael Fernandez, Leopoldo Suescun, Alvaro W. Mombrú, Jenny Saldaña, Laura Domínguez, Javier Coll, Mutue T. Fujii, Eduardo Manta
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Eleven sesquiterpenes (1-11) and one long chain aldehyde (12) have been isolated from the dichloromethane extract of the red alga Laurencia scoparia. Four of them are new natural products. Scopariol (1) is a new natural product with an unusual rearranged chamigrane-type structure. The other three are beta-chamigrenes: isorigidol (2), (+)-3-(Z)-bromomethylidene-10 beta-bromo-beta-chamigrene (3), and (-)-3-(E)-bromomethylidene-10 beta-bromo-beta-chamigrene (4). The in vitro activity of compounds 1-12 against the parasitant stage of Nippostrongylus brasiliensis (L4) has been studied.