Elsevier, Tetrahedron Letters, 42(56), p. 5743-5746
DOI: 10.1016/j.tetlet.2015.08.072
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A novel and highly regio- and diastereoselective four-component reaction involving an olefin, a cyclic ether, a halogen reagent, and a sulfonic acid has been developed to access alkoxyether derivatives. Moderate to excellent yields were obtained with a broad substrate scope without external catalyst. Several of these sulfonate ester derivatives showed strong anticancer activity against human lung adenocarcinoma cells.