American Chemical Society, Langmuir, 19(29), p. 5905-5910, 2013
DOI: 10.1021/la400402a
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Confocal Raman spectroscopy was undertaken to identify separate layers of PLGA and Gentamicin sulphate (GS) coatings on titanium alloy substrate for a novel drug delivery sustem. Additionally, it was found that it was possible to accurately measure the layer thickness and uniformity of the PLGA by detecting intensity and wavelength changes in the vibrational bands of the copolymer bonds. Further analysis of the materials was done using FIB, SEM/EDX and profilometry, these techniques were used to confirm the findings of the Raman data. It was determined that the substrate was extremely rough and, therefore, the coating was not uniform in thickness but the materials were uniformly dispersed. Most importantly, there was two distinct GS and PLGA layers.