Published in
Taylor and Francis Group, OncoImmunology, 1(2), p. e22409
DOI: 10.4161/onci.22409
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- ORCID
- Taylor and Francis Group
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells
,
Isabelle Martins,
Oliver Kepp,
Lorenzo Galluzzi,
Laurence Zitvogel,
Maria Castedo,
Guido Kroemer
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Abstract
One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.