Apparent molar volume (V 2,/) and apparent molar isentropic compressibility (K s,2,/) of diclofenac sodium salt (DSS) drug within the concentration range of (0.001 to 0.008) mol Á kg À1 in (0.01, 0.03 and 0.05) mol Á kg À1 aqueous glycine and L-proline solutions are computed from the experimental density (q) and speed of sound (u) values at T = (293.15 to 313.15) K and atmospheric pressure. Derived parameters such as partial molar properties, transfer partial molar properties, hydration numbers and Hepler's constant are computed from the data of V 2,/ and K s,2,/. These parameters have been used to understand the effect of temperature on interactions between DSS drug and aqueous glycine/L-proline solution. Furthermore , the structure making and breaking ability of DSS drug in probed solutions are analysed at experimental conditions.