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Elsevier, Journal of The American Society of Echocardiography, 10(23), p. 1113.e5-1113.e7, 2010

DOI: 10.1016/j.echo.2010.03.011

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Composite Hodgkin and Non-Hodgkin Lymphoma of the Mitral and Aortic Valves

Journal article published in 2010 by Amber D. Khanna, Harold M. Burkhart, Marosh Manduch, Andrew L. Feldman ORCID, David J. Inwards, Heidi M. Connolly
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.