Wiley, Angewandte Chemie International Edition, 3(55), p. 1102-1107, 2015
Wiley, Angewandte Chemie, 3(128), p. 1114-1119, 2015
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A copper-catalyzed three-component coupling of allenes, bis(pinacolato)diboron, and imines allows regio-, chemo-, and diastereoselective assembly of branched α,β-substituted-γ-boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α-substituted-β-amino ketones. A computational study has been used to probe the stereochemical course of the cross-coupling.