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American Physical Society, Physical Review Letters, 12(90)

DOI: 10.1103/physrevlett.90.128102

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Pattern Formation inside Bacteria: Fluctuations due to the Low Copy Number of Proteins

Journal article published in 2003 by Martin Howard ORCID, Andrew D. Rutenberg
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We examine fluctuation effects due to the low copy number of proteins involved in pattern-forming dynamics within a bacterium. We focus on a stochastic model of the oscillating MinCDE protein system regulating accurate cell division in E. coli. We find that, for some parameter regions, the protein concentrations are low enough that fluctuations are essential for the generation of patterns. We also examine the role of fluctuations in constraining protein concentration levels.