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BioMed Central, BMC Research Notes, 1(7), 2014

DOI: 10.1186/1756-0500-7-775

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Reproducibility of exhaled nitric oxide measurements in overweight and obese adults

Journal article published in 2014 by Willemien Thijs, Renée de Mutsert, Saskia le Cessie ORCID, Mutsert R. De, Cessie S. Le, Saskia le Cessie, Pieter S. Hiemstra ORCID, Frits R. Rosendaal, Saskia Middeldorp, Klaus F. Rabe
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance – decreased expiratory reserve volume. Findings We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m 2 ) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970). Conclusions We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices.