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Oxford University Press (OUP), Rheumatology, 4(47), p. 484-487

DOI: 10.1093/rheumatology/ken023

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Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis

Journal article published in 2007 by P. Kümpers, R. Horn, Georg E. Brabant, A. Woywodt, M. Schiffer ORCID, H. Haller, M. Haubitz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVES: To study serum levels of leptin and ghrelin in ANCA-associated vasculitis (AAV). METHODS: Thirty-seven patients with AAV (21 patients with active AAV at initial presentation and during follow-up, 16 patients with AAV in long-term remission) and 21 matched healthy controls were included. Serum levels of leptin and ghrelin were measured at 0, 6 and 12 months by radioimmunoassay. Disease activity was gauged by Birmingham Vasculitis Activity Score (BVAS), CRP and circulating endothelial cells (CECs). RESULTS: Leptin levels were significantly lower in patients than in healthy controls (9.1 +/- 6.1 vs 22.3 +/- 22.4 ng/ml; P