Published in

Elsevier, Bioorganic and Medicinal Chemistry Letters, 15(19), p. 4122-4125

DOI: 10.1016/j.bmcl.2009.06.005

Links

Tools

Export citation

Search in Google Scholar

Synthesis and evaluation of 3”- and 4”-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

Journal article published in 2009 by Ravinder Raju, Bernard F. Castillo, Stewart K. Richardson, Meena Thakur, Ryan Severins, Mitchell Kronenberg, Amy R. Howell ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Four 3''- and 4''-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4''-fluoro analog led to the production of significant levels of IL-2.