Published in
Lippincott, Williams & Wilkins, The Pediatric Infectious Disease Journal, 4(25), p. 365-368, 2006
DOI: 10.1097/01.inf.0000207419.50016.5e
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Low immunologic response to highly active antiretroviral therapy in naive vertically human immunodeficiency virus type 1-infected children with severe immunodeficiency
,
Alejandro Alvaro-Meca,
Maria Isabel de José,
Pablo Martin-Fontelos,
Maria Dolores Gurbindo Guti??rrez,
Maria Dolores Gurbindo Gutiérrez,
Juan Antonio L??on,
Juan Antonio Léon,
José Tomás Ramos,
Luis Ciria,
Maria ??ngeles Mu??oz-Fern??ndez,
Maria Angeles Muñoz-Fernández
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Abstract
We conducted a retrospective study to analyze the CD4 recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4 of <15% did not reach a mean CD4 of > or =25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4.