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Nature Research, Nature Genetics, 11(41), p. 1191-1198, 2009

DOI: 10.1038/ng.466

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Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Journal article published in 2009 by Santhi K. Ganesh, Neil A. Zakai, Frank Ja A. van Rooij ORCID, Nicole Soranzo, Albert V. Smith ORCID, Michael A. Nalls, Ming-Huei Chen, Anna Kottgen, Nicole L. Glazer, Abbas Dehghan ORCID, Brigitte Kuhnel, Thor Aspelund, Qiong Yang, Toshiko Tanaka, Andrew Jaffe and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell count (RBC). We performed an initial GWAS in cohorts of the CHARGE Consortium totaling 24,167 individuals of European ancestry and replication in additional independent cohorts of the HaemGen Consortium totaling 9,456 individuals. We identified 23 loci significantly associated with these traits in a meta-analysis of the discovery and replication cohorts (combined P values ranging from 5 x 10(-8) to 7 x 10(-86)). Our findings include loci previously associated with these traits (HBS1L-MYB, HFE, TMPRSS6, TFR2, SPTA1) as well as new associations (EPO, TFRC, SH2B3 and 15 other loci). This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures.