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2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

DOI: 10.1109/iembs.2007.4352238

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Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample

Journal article published in 2007 by Alexandre Perera ORCID, Alfonso Buil ORCID, Maria Chiara Di Bernardo, Maria Sabater Lleal, Linda Pattini, Juan Carlos Souto, Jordi Fontcuberta, Montserrat Vallverdu, Jose Manuel Soria, Pere Caminal
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This paper is available in a repository.

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Abstract

This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.