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Wiley, Journal of Gastroenterology and Hepatology, 8(29), p. 1637-1644, 2014

DOI: 10.1111/jgh.12576

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Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)

Journal article published in 2014 by Caterina Pozzan, Romilda Cardin, Marika Piciocchi, Nora Cazzagon, Gemma Maddalo, Veronica Vanin, Anna Giacomin, Patrizia Pontisso ORCID, Umberto Cillo, Fabio Farinati ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND AND AIM: The serpin squamous cell carcinoma antigen complexed with IgM (SCCA-IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA-IgM diagnostic accuracy and to determine its prognostic role. METHODS: SCCA-IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated. RESULTS: HCC patients had SCCA-IgM levels significantly higher than controls and cirrhotics (p