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American Chemical Society, Organic Letters, 10(9), p. 1943-1946, 2007

DOI: 10.1021/ol070526p

Wiley-VCH Verlag, ChemInform, 37(38), 2007

DOI: 10.1002/chin.200737072

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Highly Enantioselective α-Aminoxylation of Aldehydes and Ketones with a Polymer-Supported Organocatalyst

Journal article published in 2007 by Daniel Font, Amaia Bastero, Sonia Sayalero, Ciril Jimeno, Miquel A. Pericàs ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The first catalytic enantioselective alpha-aminoxylation of aldehydes and ketones using an insoluble, polymer-supported organocatalyst (1) derived from trans-4-hydroxyproline is reported (ee: 96-99%). Reaction rates in the aminoxylation of cyclic ketones with 1 are higher than those reported with l-proline. The insoluble nature of 1 simplifies workup conditions and allows catalyst recycling without an apparent decrease in enantioselectivity or yield.