Published in
J. epilepsy clin. neurophysiol., 3(16), p. 97-99
DOI: 10.1590/s1676-26492010000300003
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A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina
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Rb Marchesini,
Ahb Matos,
Ff Conte,
Tc Pereira,
R. Gilioli,
Jm Malheiros,
Rs Polli,
Hh Buzzá,
A. Tannús,
L. Covolan,
Ea Cavalheiro,
L. Velloso,
F. Cendes,
I. Lopes-Cendes
Abstract
INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.