The choice of a suitable MCMC method and further the choice of a proposal distribution is known to be crucial for the convergence of the Markov chain. However, in many cases the choice of an effective proposal distribution is difficult. As a remedy we suggest a method called Adaptive Proposal (AP). Although the stationary distribution of the AP algorithm is slightly biased, it appears to provide an efficient tool for, e.g., reasonably low dimensional problems, as typically encountered in non-linear regression problems in natural sciences. As a realistic example we include a successful application of the AP algorithm in parameter estimation for the satellite instrument 'GOMOS'. In this paper we also present systematic performance criteria for comparing Adaptive Proposal algorithm with more traditional Metropolis algorithms.