Minority stress refers to a conceptual model that describes stressors embedded in the social position of sexual minority individuals as causes of health-related conditions, such as mental disorders, psychological distress, physical disorders, health behaviors (e.g., smoking, condom use), and, more generally, a sense of well-being. The minority stress model suggests that because of stigma, prejudice, and discrimination, lesbian, gay, and bisexual people experience more stress than do heterosexuals and that this stress can lead to mental and physical disorders. This chapter begins with a brief overview of the minority stress model. It then discusses the domains of health and well-being that are affected by minority stressors, including mental health, physical health, health behaviors, and well-being.