Facile and Practical Enantioselective Synthesis of Propargylic Alcohols by Direct Addition of Alkynes to Aldehydes Catalyzed by Chiral Disulfide—Oxazolidine Ligands.

Braga, Antonio L.; Appelt, Helmoz R.; Silveira, Claudio C.; Wessjohann, Ludger A.; Schneider, Paulo H.

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Wiley-VCH Verlag, ChemInform, 19(34), 2003

DOI: 10.1002/chin.200319054

Elsevier, Tetrahedron, 52(58), p. 10413-10416

DOI: 10.1016/s0040-4020(02)01420-5

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Facile and Practical Enantioselective Synthesis of Propargylic Alcohols by Direct Addition of Alkynes to Aldehydes Catalyzed by Chiral Disulfide—Oxazolidine Ligands.

Journal article published in 2002 by Antonio L. Braga

, Helmoz R. Appelt, Claudio C. Silveira, Ludger A. Wessjohann, Paulo H. Schneider

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Abstract

The enantioselective alkynylation reaction of aldehydes with alkynes and diethylzinc, catalyzed by chiral disulfide–oxazolidine ligands, provides a simple, practical and inexpensive method to access chiral propargylic alcohols in good yields and satisfactory ee's.

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Facile and Practical Enantioselective Synthesis of Propargylic Alcohols by Direct Addition of Alkynes to Aldehydes Catalyzed by Chiral Disulfide—Oxazolidine Ligands.

Abstract