Human illness caused by infection with enteric Salmonella dramatically increased worldwide and continued to be a disastrous public health concern. Salmonella enterica serovar Typhimurium (S. Typhimurium) and serovar Enteritidis (S. Enteritidis) are the primary and predominant causes of foodborne salmonellosis, that routinely contaminate eggs, in the laying farms. The antimicrobial activity of eight plant extracts against S. Typhimurium and S. Enteritidis was in vitro determined using both quantitative and qualitative assays, as natural and powerful alternatives to synthetic and chemical biocides. The most effective plant extracts, i.e. oak galls (Quercus infectoria), pomegranate peels (Punica granatum) and senna leaves (Senna alexandrina), were applied as immersion solutions and aerosols for disinfecting the experimentally contaminated eggs and sanitizing aerosolization room. Each of the examined extracts could efficiently inhibit Salmonella growth. The combination between the minimal inhibitory concentrations (MIC) from the three extracts increased their antibacterial potentiality and resulted in a complete inhibition of contaminating S. Enterica growth. The application of plant extracts, however, could be recommended as eco-friendly, safe and powerful alternatives to the frequently applied chemical sanitizers and disinfectants against the invasion of enteric Salmonella in egg farms.