Dissemin is shutting down on January 1st, 2025

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Sociedade Brasileira de Cardiologia - SBC, Arquivos Brasileiros de Cardiologia, 2014

DOI: 10.5935/abc.20140171

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Late Outcome of a Randomized Study on Oral Magnesium for Premature Complexes

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Preprint: policy unknown
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Postprint: policy unknown
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Data provided by SHERPA/RoMEO

Abstract

Background: Ventricular and supraventricular premature complexes (PC) are frequent and usually symptomatic. According to a previous study, magnesium pidolate (MgP) administration to symptomatic patients can improve the PC density and symptoms. Objective: To assess the late follow-up of that clinical intervention in patients treated with MgP or placebo. Methods: In the first phase of the study, 90 symptomatic and consecutive patients with PC were randomized (double-blind) to receive either MgP or placebo for 30 days. Monthly follow-up visits were conducted for 15 months to assess symptoms and control electrolytes. 24-hour Holter was performed twice, regardless of symptoms, or whenever symptoms were present. In the second phase of the study, relapsing patients, who had received MgP or placebo (crossing-over) in the first phase, were treated with MgP according to the same protocol. Results: Of the 45 patients initially treated with MgP, 17 (37.8%) relapsed during the 15-month follow-up, and the relapse time varied. Relapsing patients treated again had a statistically significant reduction in the PC density of 138.25/hour (p