Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 31(112), p. 9608-9613, 2015

DOI: 10.1073/pnas.1422605112

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Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

Journal article published in 2015 by Brahim Heddi, Vee Cheong, Herry Martadinata, Anh Tuân Phan ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Significance G-quadruplexes (G4) are four-stranded nucleic acid structures implicated in important biological processes. Interaction between G4 and proteins is essential for the cellular functions of G4. The DEAH (Asp-Glu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (also named DHX36 or G4R1) specifically binds and unwinds G4 structures. The structure of an 18-aa peptide, identified as the G4-binding domain of RHAU, was solved in the complex with a G4 by NMR spectroscopy. The structure of the complex explains how RHAU specifically recognizes G4 structures and suggests a strategy for G4 recognition by proteins.