Oxford University Press (OUP), Bioinformatics, 22(30), p. 3143-3151
DOI: 10.1093/bioinformatics/btu519
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The identification of active transcriptional regulatory elements is crucial to understand regulatory networks driving cellular processes such as cell development and the onset of diseases. It has recently been shown that chromatin structure information, such as DNase I hypersensitivity or histone modifications, significantly improves cell-specific predictions of transcription factor binding sites. However, no method have so far successfully combined both DNase I hypersensitivity and histone modification data to perform active binding site prediction.